<META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=iso-8859-7"> <html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns="http://www.w3.org/TR/REC-html40"> <head> <meta name=Generator content="Microsoft Word 11 (filtered medium)">  <style>  </style> </head> <body lang=EN-US link=blue vlink=blue bottomMargin=0 leftmargin=3 topmargin=0 rightMargin=3> <div class=Section1> Thanks Dan,<o:p></o:p> <o:p> </o:p> Here’s what I found on Toluene; (I guess I’ll be wearing a respirator)<o:p></o:p> <o:p> </o:p> Jim Busby <o:p></o:p> <o:p> </o:p> <o:p> </o:p> <o:p> </o:p> Main article: <a href="http://en.wikipedia.org/wiki/Toluene_%28toxicology%29" title="Toluene (toxicology)">Toluene (toxicology)</a><o:p></o:p> Inhalation of toluene fumes can be intoxicating, but in larger doses nausea-inducing. <a href="http://en.wikipedia.org/wiki/Volatile_substance_abuse" title="Volatile substance abuse">Chronic or frequent inhalation</a> of toluene over long time periods leads to irreversible <a href="http://en.wikipedia.org/wiki/Brain_damage" title="Brain damage">brain damage</a>. Toluene may enter the human system not only through vapour inhalation from the liquid evaporation, but also following <a href="http://en.wikipedia.org/wiki/Soil_contamination" title="Soil contamination">soil contamination</a> events, where human contact with soil, ingestion of contaminated groundwater or soil vapour off-gassing can occur.<o:p></o:p> The toxicity of toluene can be explained mostly by its metabolism. As toluene has very low water solubility, it cannot exit the body via the normal routes (urine, feces, or sweat). It must be metabolized in order to be excreted. The methyl group of toluene is more easily oxidized by <a href="http://en.wikipedia.org/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> than the benzene ring. Therefore, in the metabolism of toluene, 95% is oxidized to become <a href="http://en.wikipedia.org/wiki/Benzyl_alcohol" title="Benzyl alcohol">benzyl alcohol</a>. The toxic metabolites are created by the remaining 5% that are ring oxidized to epoxides. Most of the epoxides become <a href="http://en.wikipedia.org/wiki/Glutathione" title=Glutathione>glutathione</a> conjugated. However, the remainder will severely damage cells.<o:p></o:p> <h2 style='background:#F8FCFF'><a name="Behavioural_Effects_of_Long_Term_Exposur"></a>[<a href="http://en.wikipedia.org/w/index.php?title=Toluene&action=edit&section=6" title="Edit section: Behavioural Effects of Long Term Exposure">edit</a>] Behavioural Effects of Long Term Exposure<o:p></o:p></h2> Serious adverse behavioural effects are often associated with toluene abuse related to the deliberate inhalation of solvents.4 Long term toluene exposure is often associated with effects such as: <a href="http://en.wikipedia.org/wiki/Psychoorganic_syndrome" title="Psychoorganic syndrome">psychoorganic syndrome</a>;5 visual evoked potential (VEP) abnormality;5 toxic <a href="http://en.wikipedia.org/wiki/Neuropathy" title=Neuropathy>polyneuropathy</a>, <a href="http://en.wikipedia.org/wiki/Cerebellum" title=Cerebellum>cerebellar</a>, <a href="http://en.wikipedia.org/wiki/Cognitive" title=Cognitive>cognitive</a>, and <a href="http://en.wikipedia.org/wiki/Pyramidal_cells" title="Pyramidal cells">pyramidal dysfunctions</a>;5 <a href="http://en.wikipedia.org/wiki/Atrophy" title=Atrophy>optic atrophy</a>; and <a href="http://en.wikipedia.org/wiki/Lesion" title=Lesion>brain lesions</a>.4<o:p></o:p> Toluene causes postural tremors by increasing extracellular concentrations of <a href="http://en.wikipedia.org/wiki/%CE%93-aminobutyric_acid" title="Γ-aminobutyric acid">ă-aminobutyric acid</a> (<a href="http://en.wikipedia.org/wiki/GABA" title=GABA>GABA</a>) within the <a href="http://en.wikipedia.org/wiki/Cerebellar_cortex" title="Cerebellar cortex">cerebellar cortex</a>.4 Treatment with <a href="http://en.wikipedia.org/wiki/GABA" title=GABA>GABA</a> agonists such as, <a href="http://en.wikipedia.org/wiki/Benzodiazepines" title=Benzodiazepines>benzodiazepines</a> provide some relief from toluene induced tremor and <a href="http://en.wikipedia.org/wiki/Ataxia" title=Ataxia>ataxia</a>.4 An alternative to drug treatment is <a href="http://en.wikipedia.org/wiki/Thalamotomy" title=Thalamotomy>vim thalamotomy</a>.4 The tremors associated with toluene misuse do not seem to be a transient symptom, but an irreversible and progressive symptom which continues after solvent abuse has been discontinued.4<o:p></o:p> There is some evidence that low level toluene exposure may cause disruption in the differentiation of <a href="http://en.wikipedia.org/wiki/Astrocyte" title=Astrocyte>astrocyte</a> precursor cells.6 This does not appear to be a major hazard to adults; however, exposure of pregnant women to toluene during critical stages of fetal development could cause serious disruption to neuronal development.6<a name="See_also"></a><o:p></o:p> <o:p> </o:p> <div> <div class=MsoNormal align=center style='text-align:center'> <hr size=2 width="100%" align=center tabindex=-1> </div> From: caut-bounces@ptg.org [mailto:caut-bounces@ptg.org] On Behalf Of dan l tassin Sent: Thursday, November 09, 2006 9:46 PM To: caut@ptg.org Subject: [CAUT] gorilla glue<o:p></o:p> </div> <o:p> </o:p> <div> Jim,<o:p></o:p> </div> <div>  <o:p></o:p> </div> <div> Try Toluene.<o:p></o:p> </div> <div> You can buy it at Lowes by the gallon.<o:p></o:p> </div> <div> It's used in the AirCraft Industry to loosen solvents, glues, contact cements, etc., for<o:p></o:p> </div> <div> removal of panels, wood pieces, etc.  I once worked on helicopters.  That's the stuff<o:p></o:p> </div> <div> that's used for glue softening/removal in the hangers.  Be sure to use your gloves, <o:p></o:p> </div> <div> plenty of ventilation and air flow.  One doesn't want to smell / breath that stuff.  But, >>>  IT  WORKS !!!<o:p></o:p> </div> <div> Oh, and it air drys quickly.  So, soak the glue / parts  =  that's OK.<o:p></o:p> </div> <div>  <o:p></o:p> </div> <div> Dan Tassin, RPT<o:p></o:p> </div> <div>  <o:p></o:p> </div> <div> <o:p> </o:p> </div> </div> </body> </html>