[CAUT] gorilla glue

[Jim Busby]

Thanks Dan,

 

Here's what I found on Toluene; (I guess I'll be wearing a respirator)

 

Jim Busby 

 

 

 

Main article: Toluene (toxicology) <http://en.wikipedia.org/wiki/Toluene_%28toxicology%29> 

Inhalation of toluene fumes can be intoxicating, but in larger doses nausea-inducing. Chronic or frequent inhalation <http://en.wikipedia.org/wiki/Volatile_substance_abuse>  of toluene over long time periods leads to irreversible brain damage <http://en.wikipedia.org/wiki/Brain_damage> . Toluene may enter the human system not only through vapour inhalation from the liquid evaporation, but also following soil contamination <http://en.wikipedia.org/wiki/Soil_contamination>  events, where human contact with soil, ingestion of contaminated groundwater or soil vapour off-gassing can occur.

The toxicity of toluene can be explained mostly by its metabolism. As toluene has very low water solubility, it cannot exit the body via the normal routes (urine, feces, or sweat). It must be metabolized in order to be excreted. The methyl group of toluene is more easily oxidized by cytochrome P450 <http://en.wikipedia.org/wiki/Cytochrome_P450>  than the benzene ring. Therefore, in the metabolism of toluene, 95% is oxidized to become benzyl alcohol <http://en.wikipedia.org/wiki/Benzyl_alcohol> . The toxic metabolites are created by the remaining 5% that are ring oxidized to epoxides. Most of the epoxides become glutathione <http://en.wikipedia.org/wiki/Glutathione>  conjugated. However, the remainder will severely damage cells.


[edit <http://en.wikipedia.org/w/index.php?title=Toluene&action=edit&section=6> ] Behavioural Effects of Long Term Exposure


Serious adverse behavioural effects are often associated with toluene abuse related to the deliberate inhalation of solvents.4 Long term toluene exposure is often associated with effects such as: psychoorganic syndrome <http://en.wikipedia.org/wiki/Psychoorganic_syndrome> ;5 visual evoked potential (VEP) abnormality;5 toxic polyneuropathy <http://en.wikipedia.org/wiki/Neuropathy> , cerebellar <http://en.wikipedia.org/wiki/Cerebellum> , cognitive <http://en.wikipedia.org/wiki/Cognitive> , and pyramidal dysfunctions <http://en.wikipedia.org/wiki/Pyramidal_cells> ;5 optic atrophy <http://en.wikipedia.org/wiki/Atrophy> ; and brain lesions <http://en.wikipedia.org/wiki/Lesion> .4

Toluene causes postural tremors by increasing extracellular concentrations of γ-aminobutyric acid <http://en.wikipedia.org/wiki/%CE%93-aminobutyric_acid>  (GABA <http://en.wikipedia.org/wiki/GABA> ) within the cerebellar cortex <http://en.wikipedia.org/wiki/Cerebellar_cortex> .4 Treatment with GABA <http://en.wikipedia.org/wiki/GABA>  agonists such as, benzodiazepines <http://en.wikipedia.org/wiki/Benzodiazepines>  provide some relief from toluene induced tremor and ataxia <http://en.wikipedia.org/wiki/Ataxia> .4 An alternative to drug treatment is vim thalamotomy <http://en.wikipedia.org/wiki/Thalamotomy> .4 The tremors associated with toluene misuse do not seem to be a transient symptom, but an irreversible and progressive symptom which continues after solvent abuse has been discontinued.4

There is some evidence that low level toluene exposure may cause disruption in the differentiation of astrocyte <http://en.wikipedia.org/wiki/Astrocyte>  precursor cells.6 This does not appear to be a major hazard to adults; however, exposure of pregnant women to toluene during critical stages of fetal development could cause serious disruption to neuronal development.6

 

________________________________

From: caut-bounces at ptg.org [mailto:caut-bounces at ptg.org] On Behalf Of dan l tassin
Sent: Thursday, November 09, 2006 9:46 PM
To: caut at ptg.org
Subject: [CAUT] gorilla glue

 

Jim,

 

Try Toluene.

You can buy it at Lowes by the gallon.

It's used in the AirCraft Industry to loosen solvents, glues, contact cements, etc., for

removal of panels, wood pieces, etc.  I once worked on helicopters.  That's the stuff

that's used for glue softening/removal in the hangers.  Be sure to use your gloves, 

plenty of ventilation and air flow.  One doesn't want to smell / breath that stuff.  But, >>>  IT  WORKS !!!

Oh, and it air drys quickly.  So, soak the glue / parts  =  that's OK.

 

Dan Tassin, RPT

 

 

-------------- next part --------------
An HTML attachment was scrubbed...
URL: https://www.moypiano.com/ptg/caut.php/attachments/20061110/fd9964f6/attachment.html